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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-SGSS05NS
SGSS05NS

Chemical Structure : SGSS05NS

CAS No.: 1821409-14-6

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SGSS05NS

货号: PC-26274Not For Human Use, Lab Use Only.

SGSS05NS is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 0.54 uM, covalently modifies SETD8 at Cys311.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SGSS05NS is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 0.54 uM, covalently modifies SETD8 at Cys311.

    物理化学性质&存储条件

    分子量 364.46
    分子式 C21H20N2O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-methylpiperazin-1-yl)-3-(phenylthio)naphthalene-1,4-dione

    参考文献

    1. Shi Chen, et al. Elife. 2019 May 13:8:e45403.

    2. Patent WO2015172076A1.

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