SGPL1 inhibitor THI | SGPL1 inhibitor | Probechem Biochemicals

Chemical Structure : SGPL1 inhibitor THI

CAS No.: 94944-70-4

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SGPL1 inhibitor THI (2-Acetyl-4(5)-tetrahydroxybutylimidazole)

货号: PC-49430Not For Human Use, Lab Use Only.

2-acetyl-5-tetrahydroxybutyl imidazole (SGPL1 inhibitor THI) is a small molecule inhibitor of sphingosine-1- phosphate lyase (SGPL1) reduced cell apoptosis in different in vitro huntington's disease (HD) models.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

2-acetyl-5-tetrahydroxybutyl imidazole (SGPL1 inhibitor THI) is a small molecule inhibitor of sphingosine-1- phosphate lyase (SGPL1) reduced cell apoptosis in different in vitro huntington's disease (HD) models.
THI mitigated motor dysfunctions in both mouse and fly models of HD.
THI evoked the activation of pro-survival pathways, normalized levels of brain-derived neurotrophic factor, preserved white matter integrity, and stimulated synaptic functions in HD mice.
THI restored normal levels of hexosylceramides and stimulated the autophagic and lysosomal machinery, facilitating the reduction of nuclear inclusions of both wild-type and mutant huntingtin proteins.

物理化学性质&存储条件

分子量	230.220
分子式	C9H14N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethan-1-one

参考文献

1. Di Pardo A, et al. Sci Rep. 2017 Jul 13;7(1):5280.

2. Thomas A Vollmuth, et al. Food Chem Toxicol. 2018 Jan;111:578-596.

3. Giuseppe Pepe, et al. Mol Ther. 2022 Sep 16;S1525-0016(22)00558-5.

SGPL1 inhibitor THI (2-Acetyl-4(5)-tetrahydroxybutylimidazole)

生物&药学活性

物理化学性质&存储条件

参考文献

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SGPL1 inhibitor THI (2-Acetyl-4(5)-tetrahydroxybutylimidazole)

生物&药学活性

物理化学性质&存储条件

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