SGL5213 | SGLT inhibitor | Probechem Biochemicals

Chemical Structure : SGL5213

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SGL5213 (SGL 5213)

货号: PC-49671Not For Human Use, Lab Use Only.

SGL5213 (SGL 5213) is potent, intestinal sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 29 and 20 nM for hSGLT1 and hSDGLT2, respectively.

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生物&药学活性

SGL5213 (SGL 5213) is potent, intestinal sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 29 and 20 nM for hSGLT1 and hSDGLT2, respectively.
SGL5213 had a glucose-lowering effect at 0.3 mg/kg (p.o.) in SD rats.
Orally administered SGL5213 was hardly absorbed and its distribution was restricted to the gastrointestinal lumen.
SGL5213 significantly improved post-prandial hyperglycemia in streptozotocin (STZ)-induced diabetic rats at doses of 1 mg/kg or more.
SGL5213 suppressed intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.

物理化学性质&存储条件

分子量	669.85
分子式	C37H55N3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3E)-N-[2-[[2-(Dimethylamino)ethyl]amino]-1,1-dimethyl-2-oxoethyl]-4-[4-[[5-β-D-glucopyranosyl-4-methoxy-2-(1-methylethyl)phenyl]methyl]phenyl]-2,2-dimethyl-3-butenamide

参考文献

1. Kuroda S, et al. Bioorg Med Chem. 2019 Jan 15;27(2):394-409.

2. Io F, et al. Eur J Pharmacol. 2019 Jun 15;853:136-144.

SGL5213 (SGL 5213)

生物&药学活性

物理化学性质&存储条件

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SGL5213 (SGL 5213)

生物&药学活性

物理化学性质&存储条件

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