SGC3027 | PRMT7 inhibitor | Probechem Biochemicals

Chemical Structure : SGC3027

CAS No.: 2624313-13-7

加入收藏

SGC3027 (SGC-3027, SGC 3027)

货号: PC-72394Not For Human Use, Lab Use Only.

SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM.
SGC3027 inhibited HSP70 methylation with IC50 of 2.4 uM in C2C12 cells.
SGC3027 selectively inhibited PRMT7 but not PRMT1, 4, 5, 6, 9, and DOT1L.
SGC3027 phenocopies the genetic ablation of Prmt7, PRMT7 inhibition via SGC3027 affects cell survival after heat shock or proteasomal stress, sensitized the WT Prmt7 mouse embryonic fibroblasts (MEFs) to bortezomib.

物理化学性质&存储条件

分子量	787.373
分子式	C41H47ClN6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

参考文献

1. Szewczyk MM, et al. Nat Commun. 2020 May 14;11(1):2396.

SGC3027 (SGC-3027, SGC 3027)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SGC3027 (SGC-3027, SGC 3027)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.