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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-SGC2085
SGC2085

Chemical Structure : SGC2085

CAS No.: 1821908-48-8

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SGC2085 (SGC-2085, SGC 2085)

货号: PC-42198Not For Human Use, Lab Use Only.

SGC2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SGC2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).
SGC2085 also shows complete selectivity against a panel of 21 human protein methyltransferases.

物理化学性质&存储条件

分子量 312.4061
分子式 C19H24N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Propanamide, 2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]-, (2S)-

参考文献

1. Ferreira de Freitas R, et al. J Med Chem. 2016 Jul 28;59(14):6838-47.

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