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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-SGC-UBD1031
SGC-UBD1031

Chemical Structure : SGC-UBD1031

CAS No.: 3126240-22-7

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SGC-UBD1031 (UBD1031)

货号: PC-26833Not For Human Use, Lab Use Only.

SGC-UBD1031 (UBD1031) is a potent, specific dual USP16 and HDAC6 zinc-finger ubiquitin-binding domain (UBD) with SPR Kd of 48 nM and 16 nM respectively, disrupts the interaction between the C-terminus of ISG15 and USP16-UBD, as well as the interaction between ISG15 and HDAC6-UBD with IC50 of 1.7 uM and 1.5 uM in cellular assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SGC-UBD1031 (UBD1031) is a potent, specific dual USP16 and HDAC6 zinc-finger ubiquitin-binding domain (UBD) with SPR Kd of 48 nM and 16 nM respectively, disrupts the interaction between the C-terminus of ISG15 and USP16-UBD, as well as the interaction between ISG15 and HDAC6-UBD with IC50 of 1.7 uM and 1.5 uM in cellular assays.

物理化学性质&存储条件

分子量 449.84
分子式 C21H18ClF2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-(8-chloro-3-(2-((1-(2,6-difluorophenyl)ethyl)amino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid

参考文献

1. Silva M, et al. J Med Chem. 2026 Mar 12;69(5):5703-5711.

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