SGC-STK17B-1 |CAS:2650530-00-8 Probechem Biochemicals

Chemical Structure : SGC-STK17B-1

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SGC-STK17B-1

货号: PC-38222Not For Human Use, Lab Use Only.

SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A.

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生物&药学活性

SGC-STK17B-1 is a potent, selective, ATP-competitive inhibitor of death-associated protein kinase family member STK17B (DRAK2) with IC50 of 34 nM, >100-fold selectivity over STK17A.
SGC-STK17B-1 is also >100-fold selective over all of the other kinases tested, with only STK17A, CAMKK1, and AURKB (IC50s=5-9 uM) in panel of 403 wild type human kinase assays.
SGC-STK17B-1 demonstrated the highest cell potency in the NanoBRET target engagement assay (IC50=190 nM).
SGC-STK17B-1 is the first truly potent and selective chemical probe of STK17B.

物理化学性质&存储条件

分子量	358.448
分子式	C16H10N2O2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((6-(Benzo[b]thiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl)thio)acetic acid

参考文献

1. Alfredo Picado, et al. J Med Chem. 2020 Dec 10;63(23):14626-14646.

SGC-STK17B-1

生物&药学活性

物理化学性质&存储条件

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SGC-STK17B-1

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物理化学性质&存储条件

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