SGC-SMARCA-BRDVIII | BRM/BRG1 inhibitor | Probechem Biochemicals

Chemical Structure : SGC-SMARCA-BRDVIII

CAS No.: 1997319-84-2

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SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22)

货号: PC-73226Not For Human Use, Lab Use Only.

SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22) is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively.
SGC-SMARCA-BRDVIII displays little to no affinity for PB1(2) PB1(3) and PB1(4) (IC50=1.9->10 uM).
SGC-SMARCA-BRDVIII blocked adipocyte differentiation at 1.0 μM in 3T3-L1 murine fibroblasts.
SGC-SMARCA-BRDVIII blocks the expression of key genes during adipogenesis, including the transcription factors PPARγ and C/EBPα, and impaired the differentiation of 3T3-L1 murine fibroblasts into adipocytes.

物理化学性质&存储条件

分子量	371.441
分子式	C19H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-Butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]- piperazine-1-carboxylate

参考文献

1. Marek Wanior, et al. J Med Chem. 2020 Dec 10;63(23):14680-14699.

SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22)

生物&药学活性

物理化学性质&存储条件

参考文献

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SGC-SMARCA-BRDVIII (SMARCA-PB1 inhibitor 22)

生物&药学活性

物理化学性质&存储条件

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