SGC-NSP2PRO-1

Chemical Structure : SGC-NSP2PRO-1

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货号: PC-24207Not For Human Use, Lab Use Only.

SGC-NSP2PRO-1 is a potent, covalent inhibitor of Chikungunya virus (CHIKV) nsP2 cysteine protease (nsP2pro) with IC50 of 40 nM.

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生物&药学活性

SGC-NSP2PRO-1 is a potent, covalent inhibitor of Chikungunya virus (CHIKV) nsP2 cysteine protease (nsP2pro) with IC50 of 40 nM.
SGC-NSP2PRO-1 inhibits CHIKV nsP2 protease activity in a time-dependent manner.
SGC-NSP2PRO-1 is > 30-fold selective for CHIKV nsP2pro over the other cysteine proteases.
SGC-NSP2PRO-1 demonstrated potent inhibition of alphaviral replication using the CHIKV-nLuc and VEEV-nLuc reporter viruses with EC50= 0.05 and 0.5 µM, respectively.
SGC-NSP2PRO-1 also shows potential pan-alphaviral activity for the reduction viral titer against infectious isolates of CHIKV, MAYV, and VEEV.

物理化学性质&存储条件

分子量	350.39
分子式	C16H18N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2-ethoxyphenyl)-N-(3-(methylsulfonyl)allyl)isoxazole-5-carboxamide

参考文献

1. Ghoshal, A. et al. J. Med. Chem. 67, 16505–16532.

2. Anirban Ghoshal, et al. Res Sq. [Preprint]. 2024 Nov 12:rs.3.rs-5363451.

3. Ghoshal A, et al. Sci Rep. 2025 Mar 1;15(1):7264.

SGC-NSP2PRO-1

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物理化学性质&存储条件

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