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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-SGC-CBP30
SGC-CBP30

Chemical Structure : SGC-CBP30

CAS No.: 1613695-14-9

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SGC-CBP30 (SGC-CBP 30 )

货号: PC-21302Not For Human Use, Lab Use Only.

SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain inhibitor with Kd values of 21/32 nM, respectively.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain inhibitor with Kd values of 21/32 nM, respectively.
SGC-CBP30 shows 40-fold selectivity over the first bromodomain of BRD4 (BRD4 BD1).
SGC-CBP30 displays synergistic effects with DDR1 inhibitors in pathogenic scores, airway goblet cell counts in bronchoalveolar lavage fluid (BALF), IL-4, IFN-γ, FN1COL1 A1 secretion and α-SMA.
SGC-CBP30 reduces ZIKV-induced CCN1 up-regulation and ZIKV replication.

物理化学性质&存储条件

分子量 509.05
分子式 C28H33ClN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-(1-(2-(3-Chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-yl)propan-2-yl)morpholine

参考文献

1. Xiang Q, et al. Eur J Med Chem. 2018 Mar 10;147:238-252.

2. Sun J, et al. Virulence. 2020 Dec;11(1):113-131.

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