SG85 | Enteroviruse inhibitor | Probechem Biochemicals

Chemical Structure : SG85

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SG85 (Enterovirus 3C protease inhibitor SG85)

货号: PC-63438Not For Human Use, Lab Use Only.

SG85 is a potent Enterovirus 3C protease inhibitor with EC50 of 180 nM against EV71 and 60 nM against human rhinovirus 14 in a live virus-cell-based assay.

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生物&药学活性

SG85 is a potent Enterovirus 3C protease inhibitor with EC50 of 180 nM against EV71 and 60 nM against human rhinovirus 14 in a live virus-cell-based assay.
SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B with mean EC50 of 40 nM.
SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir.

物理化学性质&存储条件

分子量	650.773
分子式	C35H46N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (5S,8S,11S,E)-8-benzyl-5-(tert-butoxymethyl)-3,6,9-trioxo-11-(((S)-2-oxopyrrolidin-3-yl)methyl)-1-phenyl-2-oxa-4,7,10-triazatetradec-12-en-14-oate

参考文献

1. Tijsma A, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2.

2. Tan J, et al. J Virol. 2013 Apr;87(8):4339-51.

3. Lacroix C, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5814-8.

SG85 (Enterovirus 3C protease inhibitor SG85)

生物&药学活性

物理化学性质&存储条件

参考文献

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SG85 (Enterovirus 3C protease inhibitor SG85)

生物&药学活性

物理化学性质&存储条件

参考文献

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