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首页-小分子抑制剂&激动剂-Others-Other Targets-SFI003
SFI003

Chemical Structure : SFI003

CAS No.: 2361332-90-1

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SFI003 (SFI-003)

货号: PC-38631Not For Human Use, Lab Use Only.

SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM.
SFI003 blocked SRSF3 activities by directly reducing SRSF3 expression level, also markedly reduced the mRNA levels of CCDC50S and p53α and elevated the mRNA level of p53β.
SFI003 exhibits potent antitumor efficacy in vitro and in vivo, which drives apoptosis of CRC cells via the SRSF3/DHCR24/reactive oxygen species (ROS) axis.
Serine/arginine-rich splicing factor 3 (SRSF3) is an attractive member of the SR protein family.
SRSF3 plays critical roles in the regulation of RNA splicing and many other cellular functions.
SRSF3 regulates cell cycle arrest and apoptosis and promotes CRC cell growth by regulating the expression of ArhGAP30, PKM2, MAP4K4, HIPK2, etc.

物理化学性质&存储条件

分子量 363.439
分子式 C19H17N5OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-(2-(1-(1H-benzo[d]imidazol-2-yl)ethylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole

参考文献

1. Yawen Zhang, et al. Cell Death Discov. 2022 May 2;8(1):238.

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