SF2312 | Enolase inhibitor | Probechem Biochemicals

Chemical Structure : SF2312

CAS No.: 107729-45-3

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SF2312 (SF 2312)

货号: PC-20387Not For Human Use, Lab Use Only.

SF2312 (SF 2312) is a highly potent inhibitor of Enolase with IC50 of 37.9 and 42.5 nM for recombinant hENO1 and hENO2, respectively.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
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100 mg		Get quote

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生物&药学活性

SF2312 (SF 2312) is a highly potent inhibitor of Enolase with IC50 of 37.9 and 42.5 nM for recombinant hENO1 and hENO2, respectively.
SF2312 previously isolated as natural phosphonate antibiotic of unknown mode of action.
SF2312 exhibits non-competitive kinetics with respect to substrate 2-PGA but competitive kinetics at higher concentrations of inhibitor.
SF2312 is selectively toxic to ENO1-deleted glioma cells in the low μM range.
SF2312 (10 uM) selectively blocks glycolysis in ENO1-deleted glioma cells.
SF2312 proved superior to PhAH for killing ENO1-deleted versus ENO1-rescued glioma cells, especially under anaerobic conditions.

物理化学性质&存储条件

分子量	197.08
分子式	C4H8NO6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid

参考文献

1. Leonard PG, et al. Nat Chem Biol. 2016 Dec;12(12):1053-1058.

2. Watanabe H, et al. Science Reports of Meiji Seika Kaisha. 1986;(No. 25):12–17.

SF2312 (SF 2312)

生物&药学活性

物理化学性质&存储条件

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SF2312 (SF 2312)

生物&药学活性

物理化学性质&存储条件

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