SF-9-2

Chemical Structure : SF-9-2

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货号: PC-25370Not For Human Use, Lab Use Only.

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生物&药学活性

SF-9-2 is a potent, small molecule inhibitor of PD-1/PD-L1 binding with IC50 of 24.9 nM in HTRF assays, effectively suppresses the viability of NB cell line SK-N-SH with high PD-L1 expression with IC50 of 5.9 uM.
SF-9-2 inhibits the proliferation, migration, invasion, and EMT of SK-N-SH cells.
SF-9-2 (3 uM) induces mitochondrial-dependent apoptosis in SK-N-SH cells.
SF-9-2 exerts its antitumor effects by modulating MAPK pathway activity in SK-N-SH cells, SF-9-2 (5 uM) significantly reduced PD-L1 levels in SK-N-SH cells.
SF-9-2-mediated regulation of ERK phosphorylation is linked to PD-L1 inhibition.
SF-9-2 induces PD-L1 internalization and ubiquitin-proteasome pathway degradation mediated by GSK-3β.
SF-9-2 (40 mg/kg, i.p.) suppresses SK-N-SH tumor growth in SK-N-SH NOG mouse model.
SF-9-2 also acted as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function.

物理化学性质&存储条件

分子量	515.56
分子式	C30H27F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-((2'-fluoro-2-(fluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)-2-(((2-hydroxyethyl)amino)methyl)phenoxy)methyl)nicotinonitrile

参考文献

1. Wang J, et al. ACS Pharmacol Transl Sci. 2025 Jul 7;8(8):2612-2629.

SF-9-2

生物&药学活性

物理化学性质&存储条件

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SF-9-2

生物&药学活性

物理化学性质&存储条件

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