SF-3-030 | ERK inhibitor | Probechem Biochemicals

Chemical Structure : SF-3-030

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SF-3-030 (ERK1/2 inhibitor)

货号: PC-72106Not For Human Use, Lab Use Only.

SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.

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生物&药学活性

SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.
SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.
SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.
SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation.

物理化学性质&存储条件

分子量	324.365
分子式	C14H12O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,1-dioxido-2,3-dihydrothiophen-3-yl naphthalene-2-sulfonate

参考文献

1. Ramon Martinez 3rd, et al. J Pharmacol Exp Ther. 2021 Jan;376(1):84-97.

SF-3-030 (ERK1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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SF-3-030 (ERK1/2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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