SEN461 | Wnt inhibitor | Probechem Biochemicals

Chemical Structure : SEN461

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SEN461 (SEN 461)

货号: PC-49508Not For Human Use, Lab Use Only.

SEN461 (SEN 461) is a potent small molecule inhibitor of canonical WNT signaling, inhibits WNT reporter activity in the DBTRG cell line with IC50 of 1.3 uM, acts through AXIN stabilization.

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生物&药学活性

SEN461 (SEN 461) is a potent small molecule inhibitor of canonical WNT signaling, inhibits WNT reporter activity in the DBTRG cell line with IC50 of 1.3 uM, acts through AXIN stabilization.
SEN461 inhibits WNT-induced transcriptional activity and suppresses anchorage independent growth of DBTRG cells.
SEN461 increases AXIN and decreases β-CATENIN levels in DBTRG cells
SEN461 affects canonical WNT ligands mediated transcription and modulates molecular markers of the pathway.
SEN461 inhibits XWnt8-induced axis duplication in Xenopus embryos.
SEN461 shows significant in vitro activity across the panel of GBM cells with IC50 from 0.5 to 3.5 μM.
SEN461 at 30 mg/kg BID shows tumor growth inhibition of DBTRG xenograft model.

物理化学性质&存储条件

分子量	486.57
分子式	C25H34N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Methoxy-3-[[trans-4-[[4-(2-methoxyacetyl)-1-piperazinyl]carbonyl]cyclohexyl]methyl]-1-methyl-2,4(1H,3H)-quinazolinedione

参考文献

1. De Robertis A, et al. Mol Cancer Ther. 2013 Jul;12(7):1180-9.

SEN461 (SEN 461)

生物&药学活性

物理化学性质&存储条件

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SEN461 (SEN 461)

生物&药学活性

物理化学性质&存储条件

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