SEL24-B489 hydrochloride | Probechem Biochemicals

Chemical Structure : SEL24-B489 hydrochloride

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SEL24-B489 hydrochloride (SEL24)

货号: PC-63508Not For Human Use, Lab Use Only.

SEL24-B489 (SEL24) hydrochloride is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.

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生物&药学活性

SEL24-B489 (SEL24) hydrochloride is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
SEL24-B489 exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors.
SEL24-B489 decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors.
SEL24-B489 inhibits the growth of a broad panel of AML cell lines in xenograft models.

物理化学性质&存储条件

分子量	482.601
分子式	C15H19Br2ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride

参考文献

1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.

2. Białopiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.

3. Szydłowski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.

SEL24-B489 hydrochloride (SEL24)

生物&药学活性

物理化学性质&存储条件

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SEL24-B489 hydrochloride (SEL24)

生物&药学活性

物理化学性质&存储条件

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