SEA0400 (SEA-0400)

Chemical Structure : SEA0400

CAS No.: 223104-29-8

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货号: PC-73275Not For Human Use, Lab Use Only.

SEA0400 is a potent and selective Na(+)/Ca(2+) exchanger (NCX) inhibitor, inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 5-33 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
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生物&药学活性

SEA0400 (SEA-0400) is a potent and selective Na(+)/Ca(2+) exchanger (NCX) inhibitor, inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 5-33 nM.
SEA0400 is more potent than KB-R7943.
SEA0400 is NCX selective, does not affect the activities of the Na+/H+ exchanger, Na+,K+-ATPase, Ca2+-ATPase.
SEA0400 preferentially inhibits (45)Ca(2+) uptake by NCX1 compared with inhibitions by NCX2, NCX3, and NCKX2.
EA0400 also selectively blocked outward exchange currents from NCX1 transfectants.
SEA0400 protected against hypoxia/reoxygenation-induced cell damage in tubular cells expressing wild-type NCX1.
SEA0400 attenuated dose- dependently paradoxical Ca2+ challenge-induced production of reactive oxygen species, DNA ladder formation, and nuclear condensation in cultured astrocyte.
SEA0400 reduced infarct volumes after a transient middle cerebral artery occlusion in rat cerebral cortex and striatum.

物理化学性质&存储条件

分子量	371.384
分子式	C21H19F2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline

参考文献

1. Takahiro Iwamoto, et al. J Biol Chem. 2004 Feb 27;279(9):7544-53.

2. T Matsuda, et al. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56.

SEA0400 (SEA-0400)

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物理化学性质&存储条件

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SEA0400 (SEA-0400)

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