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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-SDU-071
SDU-071

Chemical Structure : SDU-071

CAS No.:

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SDU-071 (SDU071)

货号: PC-22204Not For Human Use, Lab Use Only.

SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.
SDU-071 potentially disrupts BRD4 interaction with p53 through a contact interface between pPDID and p53 REG.
SDU-071 interacts with BRD4 to disrupt its interaction with p53.
SDU-071 displays potent antiproliferation of MDA-MB-231 cells with IC50 of 10.5 μM (72 h), inhibits MDA-MB-231 cell proliferation, migration, and invasion.
SDU-071 alters cell cycle progression and induces apoptosis in MDA-MB-231 cells.
SDU-071 perturbs BRD4-regulated pathways and downregulates c-Myc and Mucin 5AC expression.
SDU-071 (50 mg/kg) inhibits tumor growth in an MDA-MB-231 orthotopic xenograft mammary tumor model, without causing serious side effects.

物理化学性质&存储条件

分子量 435.53
分子式 C28H25N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-methoxyphenyl)-2-(((4-methoxyphenyl)amino)methyl)benzo[h]quinolin-4-amine

参考文献

1. Shumei Wang, et al. ACS Pharmacol Transl Sci. 2024 Mar 12;7(4):1178-1190.

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