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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-SDT-011
SDT-011

Chemical Structure : SDT-011

CAS No.: 500275-10-5

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SDT-011 (SDT011)

货号: PC-20905Not For Human Use, Lab Use Only.

SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays.
SDT-011 does not bind cetuximab, interacts with the same residues on EGFR found to be important for the binding of EGFR mAbs cetuximab and panitumumab.
SDT-011 improves cell proliferation and EGFR activation in cell lines.
SDT-011 reactivates EGFR in ex vivo full human skin and in A431 injected mice.
SDT-011 can be delivered via a slow-release system derived from biodegradable nanoparticles that penetrate the hair follicles and sebaceous glands, within which EGFR is highly expressed.

物理化学性质&存储条件

分子量 333.33
分子式 C16H10F3N3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N#CC1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=C(C)C=C3)N=C2S1

参考文献

1. Nethanel Friedman, et al. Sci Transl Med. 2023 Jun 7;15(699):eabo0684.

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