SD133 | Cadherin 11 inhibitor | Probechem Biochemicals

Chemical Structure : SD133

CAS No.: 1239467-61-8

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SD133 (Sd-133)

货号: PC-49249Not For Human Use, Lab Use Only.

SD133 (Sd-133) is a drug-like small molecule inhibitor of adhesion molecule cadherin 11 (CDH11), binds specifically to the CDH11 binding pocket with KD of 25.2 uM in SPR assays.

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10 mg	￥3980	In stock
25 mg	￥5880	In stock
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生物&药学活性

SD133 (Sd-133) is a drug-like small molecule inhibitor of adhesion molecule cadherin 11 (CDH11), binds specifically to the CDH11 binding pocket with KD of 25.2 uM in SPR assays.
Sd-133 significantly inhibits the growth of all three CDH11 positive cell lines with an EC50 of 3 μM but has little effect on CDH11 negative MCF7 cells.
Sd-133 also inhibits MDA-MB-231 matrigel™ outgrowth at 1 μM but is inactive on control MDA-MB-435 melanoma cells (express N-cadherin) or MCF7 breast cancer cells that express E and P-cadherin.
Sd-133 inhibitsMDA-MB-231 colony formation.
SD133 (40 mg/kg and 10 mg/kg, i.p.) significantly reduces growth of pre-existing tumors in a dose-dependent manner in C57BL/6J mice engrafted with mT3 pancreatic cancer cells.

物理化学性质&存储条件

分子量	247.297
分子式	C17H13NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-phenylpyridin-3-yl)phenol

参考文献

1. Shahin Assefnia, et al. Oncotarget. 2014 Mar 30;5(6):1458-74.

2. Ivana Peran, et al. Gastroenterology. 2021 Mar;160(4):1359-1372.e13.

SD133 (Sd-133)

生物&药学活性

物理化学性质&存储条件

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SD133 (Sd-133)

生物&药学活性

物理化学性质&存储条件

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