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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-SD0006
SD0006

Chemical Structure : SD0006

CAS No.: 271576-80-8

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SD0006 (SD06, SD-0006)

货号: PC-42805Not For Human Use, Lab Use Only.

SD0006 (SD-0006, SD-06) is a potent, selective, ATP-competitive and orally bioavailable p38α inhibitor with Ki of 61 nM.

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1 mg (Free Sample) ￥280 In stock
5 mg ￥780 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SD0006 (SD-0006, SD-06) is a potent, selective, ATP-competitive and orally bioavailable p38α inhibitor with Ki of 61 nM.
SD0006 displays 8-fold selectivity over p38β (Ki=510 nM), and greater than 100-fold selectivity based upon IC50 ratios over the other MAPKs p38γ, p38δ, ERK-2 and JNK-1, -2, and -3.
SD0006 potently inhibits tumor necrosis factor-alpha (TNFalpha) release, in vitro and in vivo, with IC50 of <200 nM. 
SD0006 is effective in the rat streptococcal-cell-wall-induced arthritis model, with dramatic protective effects on paw joint integrity and bone density as shown by radiographic analysis.
SD0006 also demonstrates good oral anti-inflammatory efficacy with excellent cross-species correlation between the rat, cynomolgus monkey, and human.

物理化学性质&存储条件

分子量 397.8581
分子式 C20H20ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-

参考文献

1. Burnette BL, et al. Pharmacology. 2009;84(1):42-60.
2. Walker JK, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2634-8.

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