SD-208 |CAS:627536-09-8 Probechem Biochemicals

Chemical Structure : SD-208

CAS No.: 627536-09-8

加入收藏

SD-208 (SD 208; SD208)

货号: PC-43408Not For Human Use, Lab Use Only.

SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases.

规格	价格	库存
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3880	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases.
SD-208 inhibits the growth inhibition of TGF-beta-sensitive CCL64 cells mediated by recombinant TGF-β1 or TGF-β2 or of TGF-β-containing glioma cell supernatant with EC50 of 0.1 uM.
SD-208 inhibits constitutive and TGF-β–induced invasion of glioma cells, inhibits TGF-β signaling in immune effector cells.
SD-208 blocks TGF-β signaling in the brain and inhibits the growth of syngeneic SMA-560 experimental gliomas in vivo.

物理化学性质&存储条件

分子量	352.7529
分子式	C17H10ClFN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-

参考文献

1. Uhl M, et al. Cancer Res. 2004 Nov 1;64(21):7954-61.

2. Bonniaud P, et al. Am J Respir Crit Care Med. 2005 Apr 15;171(8):889-98.

3. Zhou L, et al. Blood. 2008 Oct 15;112(8):3434-43.

4. Hayashi T, et al. Clin Cancer Res. 2004 Nov 15;10(22):7540-6.

SD-208 (SD 208; SD208)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SD-208 (SD 208; SD208)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.