SD-1029 |CAS:118372-34-2 Probechem Biochemicals

Chemical Structure : SD-1029

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SD-1029 (SD1029;NSC 371488)

货号: PC-61666Not For Human Use, Lab Use Only.

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.

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生物&药学活性

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.
SD-1029 inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2.
SD-1029 inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.

物理化学性质&存储条件

分子量	639.3
分子式	C25H30Cl2N2O3 • 2HBr
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide

参考文献

1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605.

3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.

SD-1029 (SD1029;NSC 371488)

生物&药学活性

物理化学性质&存储条件

参考文献

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SD-1029 (SD1029;NSC 371488)

生物&药学活性

物理化学性质&存储条件

参考文献

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