SD-066-4 | ZDHHC20 inhibitor | Probechem Biochemicals

Chemical Structure : SD-066-4

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SD-066-4 (ZDHHC20 inhibitor SD-066-4)

货号: PC-22842Not For Human Use, Lab Use Only.

SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.

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生物&药学活性

SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.
SD-066-4 shows high selectivity for ZDHHC20, without effect on ZDHHC23.
SD-066-4 reduces EGFR S-acylation in Kras mutant cells and blocks the growth of Kras mutant lung tumors extending overall survival.
A specific alanine residue (alanine 144) accommodates the methyl group of SD-066-4, thus providing isoform selectivity.

物理化学性质&存储条件

分子量	273.34
分子式	C18H15N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(p-tolyl)-1H-pyrazol-3-yl)-1H-indole

参考文献

1. Lee JY, et al. bioRxiv [Preprint]. 2024 Jul 22:2024.07.18.604152.

SD-066-4 (ZDHHC20 inhibitor SD-066-4)

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SD-066-4 (ZDHHC20 inhibitor SD-066-4)

生物&药学活性

物理化学性质&存储条件

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