SCR2682 | Kv.7 activator | Probechem Biochemicals

Chemical Structure : SCR2682

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SCR2682 (SCR 2682)

货号: PC-49538Not For Human Use, Lab Use Only.

SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine.

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生物&药学活性

SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine.
SCR2682 shifts voltage-dependent activation of the Kv7.2/7.3 current toward more negative membrane potential, to about −37 mV (V1/2).
SCR2682 also activates the native M-current in rat hippocampal or cortical neurons, causing marked hyperpolarization and potent inhibition of neuronal firings.
Intraperitoneal or intragastric administration of SCR2682 results in a dose-dependent inhibition of seizures by maximal electroshock.
SCR2682 also decreases epileptiform discharges in KA-induced seizures

物理化学性质&存储条件

分子量	435.424
分子式	C21H27BrN2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide

参考文献

1. Wang J, et al. J Pharmacol Exp Ther. 2021 Apr;377(1):20-28.

2. Zhuang XF, et al. J Pharmacol Exp Ther. 2022 Nov 17:JPET-AR-2022-001328.

SCR2682 (SCR 2682)

生物&药学活性

物理化学性质&存储条件

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SCR2682 (SCR 2682)

生物&药学活性

物理化学性质&存储条件

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