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首页-小分子抑制剂&激动剂-Others-Other Targets-SCR-1481B1
SCR-1481B1

Chemical Structure : SCR-1481B1

CAS No.: 1174161-86-4

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SCR-1481B1 (Metatinib anhydrous, Compound 68)

货号: PC-23813Not For Human Use, Lab Use Only.

SCR-1481B1 (Metatinib anhydrous, Compound 68) is a specific small molecule inhibitor of gasdermin D (GSDMD) targeting the GSDMD N-terminal oligomerization interface I (MST KD=0.4 uM), exert pyroptosis inhibitory effects, also shows inhibition on Met activation VEGFR.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg ￥5580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SCR-1481B1 (Metatinib anhydrous, Compound 68) is a specific small molecule inhibitor of gasdermin D (GSDMD) targeting the GSDMD N-terminal oligomerization interface I (MST KD=0.4 uM), exert pyroptosis inhibitory effects, also shows inhibition on Met activation VEGFR.
SCR-1481B1 (Metatinib anhydrous, Compound 68) significantly inhibited the release of LDH and IL-1β from iBMDM cells primed with LPS.
SCR-1481B1 (Metatinib anhydrous, Compound 68) specifically inhibit GSDMD N-terminal oligomerization.
SCR-1481B1 (Metatinib anhydrous, Compound 68) does not affect the cytotoxicity induced by GSDME N-terminal fragment and its oligomerization in HEK293T cells.
SCR-1481B1 (Metatinib anhydrous, Compound 68) specifically blocks GSDMD-mediated pyroptosis downstream of inflammasome activation.
SCR-1481B1 (Metatinib anhydrous, Compound 68) (10 mg/kg) significantly alleviate mouse sepsis in murine model of sepsis.
Combination SCR-1481B1 (Metatinib anhydrous, Compound 68) and PD-L1 antibody significantly enhances anti-tumor efficacy.

物理化学性质&存储条件

分子量 821.12
分子式 C32H40ClF2N6O13P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3(4H)-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1-[(phosphonooxy)methyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:2)

参考文献

1. Hu Y, et al. Cell Chem Biol. 2024 Dec 19;31(12):2024-2038.e7.

2. Patent WO 2009094417 A1

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