SCO-792 | Enteropeptidase inhibitor | Probechem Biochemicals

Chemical Structure : SCO-792

CAS No.: 1802888-04-5

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SCO-792 (Sucunamostat, SCO792, TAK792)

货号: PC-73066Not For Human Use, Lab Use Only.

SCO-792 (SCO792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.

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10 mg	￥7580	In stock
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生物&药学活性

Sucunamostat (SCO-792, TAK792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.
SCO-792 displayed high selectivity against other serine proteases, showed < 50% inhibitory activity against chymotrypsin, DPP‐4, factor XIIa, factor Xa, and thrombin at 10 uM.
SCO‐792 inhibited plasma kallikrein with an IC50 value of 16 nM and plasmin with an IC50 value of 460 nM , also inhibited trypsin with an IC50 value of 3.3 nM.
SCO‐792 effectively and dose‐dependently inhibited plasma BCAA elevations induced by oral protein dosing in rats.

物理化学性质&存储条件

分子量	470.43
分子式	C22H22N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-6-((4-guanidinobenzoyl)oxy)-2,3-dihydrobenzofuran-3-carbonyl)-L-aspartic acid hydrate

参考文献

1. Yashiro H, et al. Diabetes Obes Metab. 2019 Oct;21(10):2228-2239.

2. Sasaki M, et al. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517.

SCO-792 (Sucunamostat, SCO792, TAK792)

生物&药学活性

物理化学性质&存储条件

参考文献

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SCO-792 (Sucunamostat, SCO792, TAK792)

生物&药学活性

物理化学性质&存储条件

参考文献

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