SCO-267 | GPR40 agonist | Probechem Biochemicals

Chemical Structure : SCO-267

CAS No.: 1656261-09-4

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SCO-267 (SCO267)

货号: PC-72109Not For Human Use, Lab Use Only.

SCO-267 (SCO267) is a potent, orally available GPR40/FFAR1 full agonist with EC50 of 12 nM (hGPR40).

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

SCO-267 (SCO267) is a potent, orally available GPR40/FFAR1 full agonist with EC50 of 12 nM (hGPR40).
SCO-267 activated Gq signaling in both high- and low-FFAR1-expressing CHO cells, increased insulin, glucagon, GLP-1, glucose-dependent insulinotropic peptide, and peptide YY (PYY) secretions under nonfasting conditions in rats, induced GLP-1 secretion, food intake inhibition, and body weight reduction in mice.
SCO-267 effectively stimulated insulin secretion and GLP-1 release and ameliorated glucose tolerance in diabetic rats via GPR40 full agonism.

物理化学性质&存储条件

分子量	614.787
分子式	C36H46N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-Cyclopropyl-3-(2-((1-(5-methoxy-2-((6-methylpyridin-2-yl)(neopentyl)carbamoyl)phenyl)piperidin-4-yl)methoxy)pyridin-4-yl)propanoic acid

参考文献

1. Hikaru Ueno, et al. J Pharmacol Exp Ther. 2019 Aug;370(2):172-181.

2. Hideki Furukawa, et al. J Med Chem. 2020 Sep 24;63(18):10352-10379.

SCO-267 (SCO267)

生物&药学活性

物理化学性质&存储条件

参考文献

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SCO-267 (SCO267)

生物&药学活性

物理化学性质&存储条件

参考文献

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