SCIO-469 |CAS:309913-83-5 Probechem Biochemicals

Chemical Structure : SCIO-469

CAS No.: 309913-83-5

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SCIO-469 (Talmapimod;SCIO469;SCIO 469)

货号: PC-42566Not For Human Use, Lab Use Only.

Talmapimod (SCIO469) is a potent, selective p38α MAPK inhibitor with IC50 of 9 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

Talmapimod (SCIO469) is a potent, selective p38α MAPK inhibitor with IC50 of 9 nM.
Talmapimod (SCIO469) displays 10-fold selectivity for p38α over p38β, >2,000-fold selectivity over a panel of 20 other kinases, including other MAP kinases.
Talmapimod (SCIO469) decreases apoptosis in MDS CD34+ progenitors and leads to dose-dependant increases in erythroid and myeloid colony formation.
Talmapimod (SCIO469) enhances the ability of MG132 and bortezomib to induce the apoptosis of MM cells, and inhibits tumor growth in vivo.

物理化学性质&存储条件

分子量	513.0035
分子式	C27H30ClFN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-

参考文献

1. Navas TA, et al. Leukemia. 2006 Jun;20(6):1017-27.

2. Navas TA, et al. Blood. 2006 Dec 15;108(13):4170-7.

3. Hideshima T, et al. Oncogene. 2004 Nov 18;23(54):8766-76.

SCIO-469 (Talmapimod;SCIO469;SCIO 469)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

SCIO-469 (Talmapimod;SCIO469;SCIO 469)

生物&药学活性

物理化学性质&存储条件

参考文献

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