SCIC2.1 | SIRT1 activator | Probechem Biochemicals

Chemical Structure : SCIC2.1

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SCIC2.1 (SIRT1 activator)

货号: PC-49474Not For Human Use, Lab Use Only.

SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SCIC2.1 is a potent small molecule SIRT1 activator (Emax=175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.
SCIC2.1 is cell permeable and does not affect cell growth.
SCIC2.1 (25 uM) potentiates SIRT1-mediated effects in stress response, enhances SIRT1-dependent p53 deacetylation.

物理化学性质&存储条件

分子量	313.328
分子式	C18H16FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-fluorobenzyl)(methyl)amino)methyl)-7-hydroxy-2H-chromen-2-one

参考文献

1. Lucia Scisciola, et al. Epigenetics. 2020 Jun-Jul;15(6-7):664-683.