SCH772984 | ERK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : SCH772984

CAS No.: 942183-80-4

加入收藏

SCH772984 (SCH 772984, SCH-772984)

货号: PC-45868Not For Human Use, Lab Use Only.

SCH772984 is a potent and selective inhibitor of ERK1/ERK2 with IC50 of 4 nM/1 nM, respectively.

规格	价格	库存
2 mg	￥880	In stock
5 mg	￥1280	In stock
10 mg	￥1980	In stock
50 mg	￥3680	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SCH772984 is a potent and selective inhibitor of ERK1/ERK2 with IC50 of 4 nM/1 nM, respectively.
SCH772984 is highly selective, with only seven kinases of 300 showing >50% inhibition at 1 uM.
SCH772984 prevents MEK-mediated ERK phosphorylation, reduces pCRAF S289/S296/S301 phosphorylation.
SCH772984 has nanomolar cellular potency in tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models.

物理化学性质&存储条件

分子量	587.6742
分子式	C33H33N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-, (3R)-

参考文献

1. Morris EJ, et al. Cancer Discov. 2013 Jul;3(7):742-50.

2. Wong DJ, et al. Mol Cancer. 2014 Aug 20;13:194.

3. Chaikuad A, et al. Nat Chem Biol. 2014 Oct;10(10):853-60.

SCH772984 (SCH 772984, SCH-772984)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SCH772984 (SCH 772984, SCH-772984)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.