SCH 486757 |CAS:524019-25-8 Probechem Biochemicals

Chemical Structure : SCH 486757

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SCH 486757 (SCH-486757;SCH486757)

货号: PC-60798Not For Human Use, Lab Use Only.

SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.

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生物&药学活性

SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
SCH 486757 effectively suppresses cough in guinea pig capsaicin cough model, without affect on inspiratory electromyogram amplitude.

物理化学性质&存储条件

分子量	440.368
分子式	C24H23Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(bis(2-chlorophenyl)methyl)-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol

参考文献

1. McLeod RL, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20.

2. Woodcock A, et al. Lung. 2010 Jan;188 Suppl 1:S47-52.

SCH 486757 (SCH-486757;SCH486757)

生物&药学活性

物理化学性质&存储条件

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SCH 486757 (SCH-486757;SCH486757)

生物&药学活性

物理化学性质&存储条件

参考文献

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