SCH 412348 |CAS:377727-26-9 Probechem Biochemicals

Chemical Structure : SCH 412348

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SCH 412348 (SCH412348)

货号: PC-63020Not For Human Use, Lab Use Only.

SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.

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生物&药学活性

SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.
SCH 412348 has >1000-fold selectivity over all other adenosine receptors.
SCH 412348 attenuates hypolocomotion induced by the A2AR agonist CGS-21680.
SCH 412348 exhibits antidepressant-like profiles in models of behavioral despair.

物理化学性质&存储条件

分子量	465.469
分子式	C22H21F2N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[2-[4-(2,4-Difluorophenyl)-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

参考文献

1. Neustadt BR, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71.

2. Smith KM, et al. Eur J Pharmacol. 2014 Apr 5;728:31-8.

3. Grauer SM, et al. Psychopharmacology (Berl). 2014 Apr;231(7):1325-37.

SCH 412348 (SCH412348)

生物&药学活性

物理化学性质&存储条件

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SCH 412348 (SCH412348)

生物&药学活性

物理化学性质&存储条件

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