SCH 351125 |CAS:370893-06-4 Probechem Biochemicals

Chemical Structure : SCH 351125

CAS No.: 370893-06-4

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SCH 351125 (SCH-C;SCH351125;Ancriviroc)

货号: PC-70235Not For Human Use, Lab Use Only.

SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.

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5 mg	￥3480	In stock
10 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
SCH 351125 (Ancriviroc) specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells.
SCH 351125 (Ancriviroc) has broad and potent antiviral activity in vitro against primary HIV-1 isolates with IC50 of 0.4-9 nM.
SCH 351125 (Ancriviroc) strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice; has a favorable pharmacokinetic profile and orally bioavailable.

物理化学性质&存储条件

分子量	557.533
分子式	C28H37BrN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-[1,4'-bipiperidine]-1'-carbonyl)-2,4-dimethylpyridine 1-oxide

参考文献

1. Strizki JM, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23.

2. Palani A, et al. J Med Chem. 2001 Oct 11;44(21):3339-42.

3. Tremblay CL, et al. Antimicrob Agents Chemother. 2002 May;46(5):1336-9.

SCH 351125 (SCH-C;SCH351125;Ancriviroc)

生物&药学活性

物理化学性质&存储条件

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SCH 351125 (SCH-C;SCH351125;Ancriviroc)

生物&药学活性

物理化学性质&存储条件

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