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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-SCH23390 hydrochloride
SCH23390 hydrochloride

Chemical Structure : SCH23390 hydrochloride

CAS No.: 125941-87-9

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SCH23390 hydrochloride (SCH-23390 hydrochloride)

货号: PC-22147Not For Human Use, Lab Use Only.

SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.

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25 mg ￥1580 In stock
50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
SCH23390 shows high affinity to human 5-HT2C receptor with a Ki of 9.3 nM, also binds with high affinity to the 5-HT2 and 5-HT1C receptors.
SCH23390 inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel with IC50 of 268 nM.
SCH23390 (1 uM) reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells.
SCH23390 abolishes generalized seizures evoked by the chemoconvulsants.

物理化学性质&存储条件

分子量 324.25
分子式 C17H19Cl2NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride

参考文献

1. Bourne JA, et al. CNS Drug Rev. 2001 Winter;7(4):399-414.

2. Millan MJ, et al. Psychopharmacology (Berl). 2001 Jun;156(1):58-62.

3. Kuzhikandathil EV, et al. Mol Pharmacol. 2002 Jul;62(1):119-26.

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