SCH-28080 |CAS:76081-98-6 Probechem Biochemicals

Chemical Structure : SCH-28080

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SCH-28080 (SCH28080)

货号: PC-62890Not For Human Use, Lab Use Only.

SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM.

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生物&药学活性

SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM; competitively inhibits the K+-stimulated hydrolysis of ATP catalyzed by the H+,K+-ATPase with Ki of 0.12 uM; inhibits gastric ulcers provoked by aspirin, aspirin+ acid, indomethacin and stress (cold-restraint) in rats (1-30 mg/kg p.o.), shows gastric antisecretory and cytoprotective activities.

物理化学性质&存储条件

分子量	277.33
分子式	C17H15N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile

参考文献

1. Vagin O, et al. Biochemistry. 2002 Oct 22;41(42):12755-62.

2. Long JF, et al. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

3. Scott CK, et al. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.

SCH-28080 (SCH28080)

生物&药学活性

物理化学性质&存储条件

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SCH-28080 (SCH28080)

生物&药学活性

物理化学性质&存储条件

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