SCH-1473759 |CAS:1094069-99-4 Probechem Biochemicals

Chemical Structure : SCH-1473759

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SCH-1473759 (SCH1473759;SCH 1473759)

货号: PC-42611Not For Human Use, Lab Use Only.

SCH-1473759 is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.

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250 mg		Get quote

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生物&药学活性

SCH-1473759 is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
SCH-1473759 shows improved cell potency (phos-HH3 inhibition IC50=25 nM) and intrinsic aqueous solubility (11.4 mM).
SCH-1473759 demonstrated efficacy and target engagement in human tumor xenograft mouse models.

物理化学性质&存储条件

分子量	426.5385
分子式	C20H26N8OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanol, 2-[ethyl[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]amino]-2-methyl-

参考文献

1. Yu T, et al. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.

2. Basso AD, et al. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.

SCH-1473759 (SCH1473759;SCH 1473759)

生物&药学活性

物理化学性质&存储条件

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SCH-1473759 (SCH1473759;SCH 1473759)

生物&药学活性

物理化学性质&存储条件

参考文献

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