SC428 | AR NTD inhibitor | Probechem Biochemicals

Chemical Structure : SC428

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SC428 (SC 428, SC-428)

货号: PC-20758Not For Human Use, Lab Use Only.

SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect.

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生物&药学活性

SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect.
SC428 potently decreased the transactivation of AR-V7, ARv567es, as well as full-length AR (AR-FL) and its LBD mutants.
SC428 substantially suppressed androgen-stimulated AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription.
SC428 significantly attenuated AR-V7–mediated AR signaling that does not rely on androgen, hampered AR-V7 nuclear localization, and disrupted AR-V7 homodimerization.
SC428 inhibited in vitro proliferation and in vivo tumor growth of cells that expressed a high level of AR-V7 and were unresponsive to enzalutamide (ENZ) treatment.

物理化学性质&存储条件

分子量	337.32
分子式	C15H10F3N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N/C=C/C1=CC=CS1)NC2=CC=C(C#N)C(C(F)(F)F)=C2

参考文献

1. Yi Q, et al. Mol Cancer Ther. 2023 May 4;22(5):570-582.

SC428 (SC 428, SC-428)

生物&药学活性

物理化学性质&存储条件

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SC428 (SC 428, SC-428)

生物&药学活性

物理化学性质&存储条件

参考文献

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