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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Ubiquitin-activating Enzyme (E1)-SC023
SC023

Chemical Structure : SC023

CAS No.:

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SC023 (SC-023)

货号: PC-27370Not For Human Use, Lab Use Only.

SC023 is a second-generation N106 analog and small-molecule enhancer of SERCA2a SUMOylation, targets the SUMO E1 enzyme to trigger intrinsic SERCA2a SUMOylation without altering SUMO-related regulatory enzymes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SC023 is a second-generation N106 analog and small-molecule enhancer of SERCA2a SUMOylation, targets the SUMO E1 enzyme to trigger intrinsic SERCA2a SUMOylation without altering SUMO-related regulatory enzymes.
SC023 exhibits reduced off-target activity, specifically lacking the adenosine A2A and serotonin 5-HT2B receptor inhibition observed with N106.
SC023 overcomes the PK and safety limitations of N106.
SC023 significantly restored left ventricular systolic function and attenuated adverse remodeling in murine transverse aortic constriction model.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Lee A, et al. J Mol Cell Cardiol. 2026 Jul 22;218:55-66.

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