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SC-919

Chemical Structure : SC-919

CAS No.: 2245949-62-4

SC-919 (SC919)

货号: PC-72584Not For Human Use, Lab Use Only.

SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.
    SC-919 reduces the export of phosphate in 293 cells via an XPR1-dependent mechanism involving the SPX domain, reduces intracellular InsP7 levels.
    SC-919 decreases plasma phosphate levels in rats and monkeys and does not inhibit phosphate intake by the gut or phosphate reuptake by the kidney in rats.
    SC-919 decreases the plasma phosphate levels in rats with hyperphosphataemia.
    SC-919 increases the intracellular levels of ATP in an XPR1-dependent manner.
    SC-919 alleviates CKD-induced hyperphosphataemia and related parameters in adenine-treated rats.

    物理化学性质&存储条件

    分子量 407.247
    分子式 C19H16Cl2N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1s,4s)-4-((3,5-dichloropyridin-2-yl)oxy)-2'-oxospiro[cyclohexane-1,3'-indoline]-5'-carboxylic acid

    参考文献

    1. Yusuke Moritoh, et al. Nat Commun. 2021 Aug 11;12(1):4847.

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