SC-58125 | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : SC-58125

CAS No.: 162054-19-5

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SC-58125 (SC58125)

货号: PC-20235Not For Human Use, Lab Use Only.

SC-58125 is a potent, selective inhibitor of COX-2 with IC50 of 0.05 uM, without inhibition on COX-1 (IC50>10 uM).

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

SC-58125 is a potent, selective inhibitor of COX-2 with IC50 of 0.05 uM, without inhibition on COX-1 (IC50>10 uM).
SC-58125 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.
SC-58125 suppressed the inflammatory reaction and caused a marked decrease in the level of PGE2 but not TXB2 and 6-keto-PGF 1 alpha.
SC-58125 rapidly reversed paw edema and reduced the level of PGE2 in paw tissue to baseline, also reduced the expression of COX-2 mRNA and protein in the paw.

物理化学性质&存储条件

分子量	384.35
分子式	C17H12F4N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-Fluorophenyl)-1-(4-methylsulfonylphenyl)-3-trifluoromethyl-1H-pyrazole

参考文献

1. Seibert K, et al. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013-7.

2. Harada Y, et al. Prostaglandins. 1996 Jan;51(1):19-33.

3. Anderson GD, et al. J Clin Invest. 1996 Jun 1;97(11):2672-9.

SC-58125 (SC58125)

生物&药学活性

物理化学性质&存储条件

参考文献

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SC-58125 (SC58125)

生物&药学活性

物理化学性质&存储条件

参考文献

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