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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclooxygenase (COX)-SC-236
SC-236

Chemical Structure : SC-236

CAS No.: 170569-86-5

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SC-236 (SC236, SC58236)

货号: PC-61664Not For Human Use, Lab Use Only.

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.
SC-236 displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM).
SC-236 exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.

物理化学性质&存储条件

分子量 401.8
分子式 C16H11ClF3N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

参考文献

1. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65.

2. Lee A, et al. Cancer Res. 2006 Apr 15;66(8):4378-84.

3. Roche-Nagle G, et al. Br J Cancer. 2004 Jul 19;91(2):359-65.

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