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首页-小分子抑制剂&激动剂-Others-Other Targets-SBT-272
SBT-272

Chemical Structure : SBT-272

CAS No.: 2356106-71-1

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SBT-272 (Bevemipretide, SBT272)

货号: PC-49721Not For Human Use, Lab Use Only.

SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function.

规格 价格 库存 数量
2 mg ￥2880 In stock
5 mg ￥4980 In stock
10 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function.
SBT-272 significantly reduced H2O2 production in vitro in permeabilized rat cardiac fibers, reduced the production of blood urea nitrogen (BUN) and creatinin, SBT-272 (4 mg/kg) prevented ischemia-reperfusion injury to mitochondria in vivo.
SBT-272 improves mitochondrial integrity of CSMN diseased with TDP-43 pathology.
SBT-272 increases mitochondrial membrane polarization in diseased UMNs.
SBT-272 treatment improves mitochondrial motility in diseased CSMN.
SBT-272 enhances axon outgrowth of diseased CSMN, improves CSMN mitochondria ultrastructure in vivo.
SBT-272 is a small molecule in phase I clinical development with a mechanism of action that improves the integrity of IMM.

物理化学性质&存储条件

分子量 607.76
分子式 C31H45N9O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-amino-N-((S)-1-(((S)-5-amino-1-(3-benzyl-1,2,4-oxadiazol-5-yl)pentyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropan-2-yl)-5-guanidinopentanamide

参考文献

1. Mukesh Gautam, et al. Neurobiol Dis. 2023 Jan 27;178:106022.

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