SBS-873 (SBS873)

Chemical Structure : SBS-873

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货号: PC-28409Not For Human Use, Lab Use Only.

SBS-873 is a first-in-class p110α/GDH1 (Glutamate dehydrogenase 1) dual inhibitor, downregulates the p110α subunit, and suppresses PI3K/Akt/mTOR pathway, triggers ferroptotic cell death through glutathione depletion, GPX4 impairment, and lipid peroxidation.

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生物&药学活性

SBS-873 is a first-in-class p110α/GDH1 (Glutamate dehydrogenase 1) dual inhibitor, downregulates the p110α subunit, and suppresses PI3K/Akt/mTOR pathway, triggers ferroptotic cell death through glutathione depletion, GPX4 impairment, and lipid peroxidation.
SBS-873 inhibits invasion and epithelial-mesenchymal transition in TNBC.
SBS-873 exhibits antiproliferative activity across TNBC (BT-549 and Hs 578T), luminal (T47D and MCF-7), and HER2-positive (BT-474) breast cancer cell lines.
SBS-873 induces GDH1-dependent ferroptosis in TNBC cells.
SBS-873 impairs mitochondrial respiration through GDH1-dependent ferroptosis.
SBS-873 inhibits the tumor growth in BT-549 xenograft-bearing mice.
SBS-873 is capable of simultaneously impairing proliferative signaling, metabolic adaptation, metastatic potential, and redox homeostasis.

物理化学性质&存储条件

分子量	466.60
分子式	C24H30N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-ethylphenyl)-3-(1-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)piperidin-4-yl)urea

参考文献

1. Dey B, et al. Cell Signal. 2026 Sep 26:112913.

SBS-873 (SBS873)

生物&药学活性

物理化学性质&存储条件

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SBS-873 (SBS873)

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物理化学性质&存储条件

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