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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Hippo-SBP-3264
SBP-3264

Chemical Structure : SBP-3264

CAS No.: 2869148-13-8

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SBP-3264 (SBP3264)

货号: PC-72700Not For Human Use, Lab Use Only.

SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency.

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5 mg ￥4580 In stock
10 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency.
SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and possessed favorable pharmacokinetic and pharmacodynamic properties in mice.
SBP-3264 suppress the proliferation of AML cells in vitro.
SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in AML.

物理化学性质&存储条件

分子量 369.853
分子式 C19H20ClN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-(5-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)acetamide

参考文献

1. Nicole Bata, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369.

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