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首页-小分子抑制剂&激动剂-Apoptosis-IAP-SBP-0636457
SBP-0636457

Chemical Structure : SBP-0636457

CAS No.: 1422180-49-1

SBP-0636457 (SBI-0636457)

货号: PC-27418Not For Human Use, Lab Use Only.

SBP-0636457 (SBI-0636457) is a SMAC mimetic and IAP antagonist, binds to the BIR-domains of the IAP proteins with Ki of 0.27 uM, sensitizes cancer cells to TRAIL-induced apoptosis.

规格 价格 库存 数量
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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SBP-0636457 (SBI-0636457) is a SMAC mimetic and IAP antagonist, binds to the BIR-domains of the IAP proteins with Ki of 0.27 uM, sensitizes cancer cells to TRAIL-induced apoptosis.

物理化学性质&存储条件

分子量 456.59
分子式 C25H36N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4S,7S,9aS)-8,8-Dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxo-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)octahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide

参考文献

1. Finlay D, et, al. Mol Cancer Ther. 2014 Jan; 13(1): 5-15.

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