SBLR876 | RAGE inhibitor | Probechem Biochemicals

Chemical Structure : SBLR876

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SBLR876 (SBLR-876)

货号: PC-26372Not For Human Use, Lab Use Only.

SBLR876 is a potent RAGE inhibitor, inhibits AGE-RAGE binding with an IC50 of 282.2 nM, blocks downstream NF-κB signaling.

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生物&药学活性

SBLR876 is a potent RAGE inhibitor, inhibits AGE-RAGE binding with an IC50 of 282.2 nM, blocks downstream NF-κB signaling.
SBLR876 mitigates AGE-BSA–induced oxidative stress and cytotoxicity in HK-2 cells.
SBLR876 attenuates AGE-induced proinflammatory cytokine release in HK-2 cells.
SBLR876 suppresses AGE-induced NF-κB activation in HK-2 cells.
SBLR876 suppresses AGE-induced NF-κB p65 phosphorylation and nuclear translocation in HK-2 cells.

物理化学性质&存储条件

分子量	561.68
分子式	C36H35NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-([1,1'-biphenyl]-4-yl)-6-(3-((4aR,8aR)-4a-hydroxyoctahydroisoquinolin-2(1H)-yl)-3-oxopropyl)-5-methyl-7H-furo[3,2-g]chromen-7-one

参考文献

1. Mohammad Al Shahrani M, et al. Biochem Biophys Res Commun. 2026 Mar 5;811:153540.

SBLR876 (SBLR-876)

生物&药学活性

物理化学性质&存储条件

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SBLR876 (SBLR-876)

生物&药学活性

物理化学性质&存储条件

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