SBL-105 | DHODH inhibitor | Probechem Biochemicals

Chemical Structure : SBL-105

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SBL-105 (SBL105)

货号: PC-20062Not For Human Use, Lab Use Only.

SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH).

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生物&药学活性

SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH).
SBL-105 shows high binding efficacy toward DHODH with a ΔGbinding score of -10.9 kcal/mol.
SBL-105 inhibits the proliferations of THP-1 cell with a GI50 value of 60.66 nM, and TF-1 cells with GI50 value of 45.33 nM, and HL-60 and SKM-1 cells are 73.98 and 86.01 nM, respectively
SBL-105 increases S-phase cell cycle arrest and total apoptosis, also increases the differentiation marker CD11b-positive populations in both THP-1 and TF-1 cells.

物理化学性质&存储条件

分子量	300.36
分子式	C21H16O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-methylbenzylidene)-2,3-dihydro-4H-benzo[g]chromen-4-one

参考文献

1. Kamli H, et al. Oncol Res. 2022 Jan 31;28(9):899-911.

SBL-105 (SBL105)

生物&药学活性

物理化学性质&存储条件

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SBL-105 (SBL105)

生物&药学活性

物理化学性质&存储条件

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