SBI-581 | TAO3 inhibitor | Probechem Biochemicals

Chemical Structure : SBI-581

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SBI-581 (SBI 581)

货号: PC-72447Not For Human Use, Lab Use Only.

SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.

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生物&药学活性

SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.
SBI-581 showed moderate selectivity against a broad panel of kinases (MEKK3 IC50=237 nM), and displayed reasonable PK after i.p. injection.
SBI-581 treatment reduces invadopodia function, 3D growth, and extravasation in vitro and in vivo, promoted TKS5α accumulation at RAB11-positive vesicles;.
SBI-581 exerted its effects through preventing TAO3 phosphorylation of dynein subunit protein LIC2 on S202.

物理化学性质&存储条件

分子量	383.451
分子式	C24H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-((1H-indol-2-yl)methylene)-4-((4-hydroxypiperidin-4-yl)ethynyl)indolin-2-one

参考文献

1. Shinji Iizuka, et al. Cancer Res. 2021 Mar 15;81(6):1472-1485.

SBI-581 (SBI 581)

生物&药学活性

物理化学性质&存储条件

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SBI-581 (SBI 581)

生物&药学活性

物理化学性质&存储条件

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